Alarming results in the annual study that tracks chemical use by teens find one in five high school seniors has vaped nicotine in the last 30 days.
The numbers have doubled since last year, from 11 percent to 21 percent.
Irina Stepanov is a U of M researcher who studies tobacco products. They use a smoking machine to analyze the chemistry of what's inside cigarettes and electronic cigarette vapor.
Stepanov says although it is not yet proven whether e-cigarettes cause cancer, there is evidence they are hazardous.
"We don't understand the risks, long-term risks associated with exclusive electronic cigarette use. But there's a chance there are some long-term health consequences," she said.
Stepanov says it's one thing for cigarette smokers to switch to vaping. But she worries about teens becoming addicted to nicotine through e-cigarettes.
Despite the rise in vaping, cigarette smoking among seniors is at the lowest point ever.
The use of prescription opioids declined to 3.4 percent, which is way down from the high of 9.5 percent in 2004.
And binge drinking dropped nearly three percentage points this year to 14 percent, which is way lower than the high of 32 percent in 1997.
But for whatever reason, right now nicotine is the drug of choice for teens, almost exclusively through electronic cigarettes.
"Very appealing. very easy to hide. Easy to share," Stepanov said.
Officials and anti-smoking advocates are reacting to this study, calling for more education in schools on potential harms of nicotine addiction. They're also pushing for more oversight on how companies market e-cigs.